The prosecutors are seeking to utilize numerous statements which they claim show the comedian's willingness to use intoxicants to incapacitate women before assaulting them sexually.
"This demonstrates that he thinks it is okay to give women drugs to have sex with them," assistant district attorney M Stewart Ryan told Judge Steven O'Neill.
But Bill Cosby's lawyer Brian McMonagle accused prosecutors of attempting a 'back-door play' that would effectively allow them to introduce evidence of other allegations unrelated to the case. The said claims involve Andrea Constand, a former basketball coach at Temple University, who accused Cosby of giving her pills in 2004 that left her unable to resist.
Cosby has been accused of sexual assault by over 50 women, with some of the accusations stretching back decades.
The Pennsylvania case is the only criminal prosecution the 79-year-old has faced up to date.
Cosby, whose acting career and public image have been shattered by the accusations, has claimed that every sexual encounter was consensual.
During sworn depositions conducted after Cosby was sued by Constand, the icon acknowledged obtaining prescription sedatives in the 1970s and giving them to young women.
Prosecutors argued that they should be permitted to use excerpts from Cosby's autobiography and statements he made in a 1991 interview. In the interview, Cosby described the power of an aphrodisiac called 'Spanish fly' to put women in the mood.
But the entertainer's lawyers countered by arguing that the deposition system had nothing to do with Constand. The defense said that the Spanish fly comments were jokes, not evidence.
Jury selection will begin next month in Pittsburgh, hundreds of miles away.